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Arrb1tm1Jse
Targeted Allele Detail
Summary
Symbol: Arrb1tm1Jse
Name: arrestin, beta 1; targeted mutation 1, J G Seidman
MGI ID: MGI:2157962
Synonyms: Arrb1-
Gene: Arrb1  Location: Chr7:99184673-99255978 bp, + strand  Genetic Position: Chr7, 54.09 cM
Alliance: Arrb1tm1Jse page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44953
Parent Cell Line:  C1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The gene was disrupted by the insertion of a neomycin resistance cassette and vector sequences through homologous recombination. The insertion results in a defined duplication of a large region of sequence within the gene. The neo cassette is located between the redundant segments, disrupting expression. Northern analysis of total heart and kidney RNA demonstrated that no detectable transcript was present in homozygous mice. Western analysis from crude cytosolic brain preparations failed to detect protein in homozygous mice. (J:44953)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arrb1 Mutation:  28 strains or lines available
References
Original:  J:44953 Conner DA, et al., beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation. Circ Res. 1997 Dec;81(6):1021-6
All:  62 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory