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Smad1tm1Rjle
Targeted Allele Detail
Summary
Symbol: Smad1tm1Rjle
Name: SMAD family member 1; targeted mutation 1, Robert J Lechleider
MGI ID: MGI:2157982
Gene: Smad1  Location: Chr8:80065024-80126057 bp, - strand  Genetic Position: Chr8, 37.56 cM
Alliance: Smad1tm1Rjle page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73279
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Insertion of a PGK-neomycin resistance cassette into exon 3 disrupted the gene. RT-PCR analysis using primers that span the middle linker and MH2 domains did not detect transcript in homozygous mutant embryos. Western blot analysis did not detect any protein in homozygous mutant embryos. (J:73279)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad1 Mutation:  32 strains or lines available
References
Original:  J:73279 Lechleider RJ, et al., Targeted mutagenesis of smad1 reveals an essential role in chorioallantoic fusion. Dev Biol. 2001 Dec 1;240(1):157-67
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory