Atox1<Gt(IRESBetageo)3Pgr> Gene trapped Allele Detail MGI Mouse (MGI:2158341)

Atox1^{Gt(IRESBetageo)3Pgr}
Gene trapped Allele Detail

Summary

Symbol:	Atox1^{Gt(IRESBetageo)3Pgr}
Name:	antioxidant 1 copper chaperone; gene trap 3, Peter Gruss
MGI ID:	MGI:2158341
Synonyms:	Atox1^-
Gene:	Atox1 Location: Chr11:55337463-55352034 bp, - strand Genetic Position: Chr11, 33.07 cM
Alliance:	Atox1^{Gt(IRESBetageo)3Pgr} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:74249
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Gene trapped (Null/knockout, Reporter)
Mutation:		Insertion of gene trap vector
		Mutation details: The gene was disrupted by the insertion of the gene trap vector IRES Beta-geo into intron 1. Northern blot analysis on RNA derived from E12.5 embryonic fibroblasts from homozygous mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on protein derived from E12.5 embryonic fibroblasts revealed that no detectable wild-type protein was made. (J:74249)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Atox1 Mutation:	14 strains or lines available

References

Original:	J:74249 Hamza I, et al., The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6848-52
All:	6 reference(s)

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