Ccr2<tm1Mae> Targeted Allele Detail MGI Mouse (MGI:2158345)

Ccr2^tm1Mae
Targeted Allele Detail

Summary

Symbol:	Ccr2^tm1Mae
Name:	C-C motif chemokine receptor 2; targeted mutation 1, Nobuyo Maeda
MGI ID:	MGI:2158345
Synonyms:	CCR2-, Ccr2^tm1Unc
Gene:	Ccr2 Location: Chr9:123901987-123913594 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
Alliance:	Ccr2^tm1Mae page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:44561
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin selection cassette was inserted in reverse transcriptional orientation in front of the coding sequence for the first transmembrane domain of the encoded protein. Competitive binding assays demonstrated a reduction in specific binding of labeled ligand to peritoneal exudate cells derived from homozygous mice. (J:44561)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Ccr2 Mutation:	43 strains or lines available

References

Original:	J:44561 Kuziel WA, et al., Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12053-8
All:	154 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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