Mecp2<tm1Jae> Targeted Allele Detail MGI Mouse (MGI:2158353)

Mecp2^tm1Jae
Targeted Allele Detail

Summary

Symbol:	Mecp2^tm1Jae
Name:	methyl CpG binding protein 2; targeted mutation 1, Rudolf Jaenisch
MGI ID:	MGI:2158353
Synonyms:	Mecp^2lox
Gene:	Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
Alliance:	Mecp2^tm1Jae page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:67909
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: LoxP sites were inserted flanking exon 3 as follows: A single loxP site was inserted 5' to exon 3 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted 3' to exon 3. The selection cassette was removed in ES cells by Cre-mediated recombination prior to the production of chimeric mice, leaving a single loxP site in place of the selection cassette. (J:67909)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:	41 strains or lines available

References

Original:	J:67909 Chen RZ, et al., Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet. 2001 Mar;27(3):327-31
All:	33 reference(s)

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