Zmpste24<tm1Sgy> Targeted Allele Detail MGI Mouse (MGI:2158363)

Zmpste24^tm1Sgy
Targeted Allele Detail

Summary

Symbol:	Zmpste24^tm1Sgy
Name:	zinc metallopeptidase, STE24; targeted mutation 1, Steven G Young
MGI ID:	MGI:2158363
Synonyms:	Zmeste24-
Gene:	Zmpste24 Location: Chr4:120916434-120955438 bp, - strand Genetic Position: Chr4, 56.8 cM
Alliance:	Zmpste24^tm1Sgy page

CT scans illustrating bony lesions in Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mice.

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:70661
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment containing exon 8 was replaced with a floxed neomycin selection cassette. Enzymatic activity assays on liver cell membranes derived from homozygous mice demonstrated reduced or absent processing of synthetic substrates, suggesting that no functional protein is produced from this allele. (J:70661)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Zmpste24 Mutation:	32 strains or lines available

References

Original:	J:70661 Leung GK, et al., Biochemical studies of Zmpste24-deficient mice. J Biol Chem. 2001 Aug 3;276(31):29051-8
All:	26 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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