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Bcl6tm1Htno
Targeted Allele Detail
Summary
Symbol: Bcl6tm1Htno
Name: B cell leukemia/lymphoma 6; targeted mutation 1, Masahiko Hatano
MGI ID: MGI:2158436
Synonyms: Bcl6-, Bcl6tm1Tto
Gene: Bcl6  Location: Chr16:23783802-23807602 bp, - strand  Genetic Position: Chr16, 15.26 cM
Alliance: Bcl6tm1Htno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55952
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 4.0 kb genomic fragment spanning exons 3 - 6 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. Northern blot analysis of mRNA derived from kidneys of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:55952)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:  57 strains or lines available
References
Original:  J:55952 Yoshida T, et al., The role of Bcl6 in mature cardiac myocytes. Cardiovasc Res. 1999 Jun;42(3):670-9
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory