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Gli2tm2.1Alj
Targeted Allele Detail
Summary
Symbol: Gli2tm2.1Alj
Name: GLI-Kruppel family member GLI2; targeted mutation 2.1, Alexandra L Joyner
MGI ID: MGI:2158472
Synonyms: Gli2lacZ, Gli2lz, Gli2lzki
Gene: Gli2  Location: Chr1:118761862-118981349 bp, - strand  Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
Alliance: Gli2tm2.1Alj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73074
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A lacZ gene and a loxP-flanked neomycin selection cassette replaced 56 bp of exon 2, including the initiation codon. The neomycin selection cassette was removed by Cre mediated recombination in mice by crossing Gli2tm2Alj mice with NLS-cre expressing mice, and selecting for offspring that no longer had the neomycin cassette. (J:73074)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 31 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gli2 Mutation:  169 strains or lines available
References
Original:  J:73074 Bai CB, et al., Gli1 can rescue the in vivo function of Gli2. Development. 2001 Dec;128(24):5161-72
All:  35 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory