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Bmp4tm2Blh
Targeted Allele Detail
Summary
Symbol: Bmp4tm2Blh
Name: bone morphogenetic protein 4; targeted mutation 2, Brigid L Hogan
MGI ID: MGI:2158495
Synonyms: Bmp4-lacZ, Bmp4lacZ, BMP4LacZ, Bmp4lacZneo
Gene: Bmp4  Location: Chr14:46620982-46628126 bp, - strand  Genetic Position: Chr14, 23.95 cM
Alliance: Bmp4tm2Blh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53311
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A DNA fragment containing most of exon 3 and including the translation initiation codon was replaced with a lacZ gene followed by a neomycin selection cassette. A beta-galactosidase protein is expressed from this allele under the control of the endogenous promoter. (J:53311)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 153 assay results
In Structures Affected by this Mutation: 23 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:  23 strains or lines available
References
Original:  J:53311 Lawson KA, et al., Bmp4 is required for the generation of primordial germ cells in the mouse embryo [see comments]. Genes Dev. 1999 Feb 15;13(4):424-36
All:  54 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory