C1qa<tm1Mjw> Targeted Allele Detail MGI Mouse (MGI:2158701)

C1qa^tm1Mjw
Targeted Allele Detail

Summary

Symbol:	C1qa^tm1Mjw
Name:	complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1, Mark J Walport
MGI ID:	MGI:2158701
Synonyms:	C1q-, C1qa-, C1qa^tm1Barr
Gene:	C1qa Location: Chr4:136623228-136626114 bp, - strand Genetic Position: Chr4, 69.05 cM
Alliance:	C1qa^tm1Mjw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:47315
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin selection cassette was inserted into exon 1 of the gene. Northern blot analysis on samples derived from spleen and liver of homozygous mice demonstrated that no transcript is produced from this allele. Western blot and ELISA analysis confirmed that no protein was detected in samples derived from homozygous mice. (J:47315, J:194445)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any C1qa Mutation:	24 strains or lines available

References

Original:	J:47315 Botto M, et al., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies [see comments]. Nat Genet. 1998 May;19(1):56-9
All:	151 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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