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Chrnb2tm1Mdb
Targeted Allele Detail
Summary
Symbol: Chrnb2tm1Mdb
Name: cholinergic receptor nicotinic beta 2 subunit; targeted mutation 1, Mariella De Biasi
MGI ID: MGI:2158714
Synonyms: beta2-, beta2-KO
Gene: Chrnb2  Location: Chr3:89660755-89671939 bp, - strand  Genetic Position: Chr3, 39.19 cM
Alliance: Chrnb2tm1Mdb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73590
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: An 8 kb genomic fragment containing exons 1-5 was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from brain of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:73590)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrnb2 Mutation:  32 strains or lines available
References
Original:  J:73590 Xu W, et al., Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci. 1999 Nov 1;19(21):9298-305
All:  50 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory