About   Help   FAQ
Chrnb4tm1Mdb
Targeted Allele Detail
Summary
Symbol: Chrnb4tm1Mdb
Name: cholinergic receptor, nicotinic, beta polypeptide 4; targeted mutation 1, Mariella De Biasi
MGI ID: MGI:2158716
Synonyms: beta4 -
Gene: Chrnb4  Location: Chr9:54935438-54956063 bp, - strand  Genetic Position: Chr9, 29.84 cM
Alliance: Chrnb4tm1Mdb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73590
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 4.1 kb genomic fragment containing exon 5 was replaced with a puromycin selection gene and an hprt minigene. RT-PCR analysis on RNA derived from brain of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:73590)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Chrnb4 Mutation:  26 strains or lines available
References
Original:  J:73590 Xu W, et al., Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci. 1999 Nov 1;19(21):9298-305
All:  33 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory