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Nodaltm1Mku
Targeted Allele Detail
Summary
Symbol: Nodaltm1Mku
Name: nodal growth differentiation factor; targeted mutation 1, Michael R Kuehn
MGI ID: MGI:2158730
Synonyms: nodalfl1
Gene: Nodal  Location: Chr10:61253751-61261117 bp, + strand  Genetic Position: Chr10, 32.21 cM
Alliance: Nodaltm1Mku page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73506
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph, Reporter)
Mutation:    Insertion
 
Mutation details: This floxed allele was generated by insertion of the IRES beta-geo cassette directly after the stop codon in the 3rd exon. LoxP sites were inserted in the 1st intron and after the 3'UTR. The allele was assessed as a hypomorph. (J:73506)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 94 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  42 strains or lines available
References
Original:  J:73506 Lowe LA, et al., Genetic dissection of nodal function in patterning the mouse embryo. Development. 2001 May;128(10):1831-43
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory