Chrm1tm1Stl
Targeted Allele Detail
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| Symbol: |
Chrm1tm1Stl |
| Name: |
cholinergic receptor, muscarinic 1, CNS; targeted mutation 1, Susumu Tonegawa |
| MGI ID: |
MGI:2158743 |
| Synonyms: |
M1 - |
| Gene: |
Chrm1 Location: Chr19:8641369-8660970 bp, + strand Genetic Position: Chr19, 5.44 cM
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| Alliance: |
Chrm1tm1Stl page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:73448
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 3 kb genomic fragment containing the entire coding region of the gene was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from forebrain of homozygous mice demonstrated that no detectable transcript was produced from this allele. In situ hybridization analysis on sagittal brain sections of homozygous mice further confirmed that the transcript was not expressed.
(J:73448)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:73448 Gerber DJ, et al., Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15312-7 |
| All: |
9 reference(s) |
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Analysis Tools
