Chrna4tm1Lst
Targeted Allele Detail
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| Symbol: |
Chrna4tm1Lst |
| Name: |
cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, Henry A Lester |
| MGI ID: |
MGI:2158758 |
| Synonyms: |
L9'S, Leu-9'Ser, neo-intact line |
| Gene: |
Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
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| Alliance: |
Chrna4tm1Lst page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:67863
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Point mutations were introduced into exon 5 to alter a residue in the fourth transmembrane domain from a leucine to a serine. A loxP flanked neomycin selection cassette was also inserted into an adjacent intron.
(J:67863)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Chrna4 Mutation: |
44 strains or lines available
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| Original: |
J:67863 Labarca C, et al., Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2786-91 |
| All: |
5 reference(s) |
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Analysis Tools
