Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Gpx1tm1Ysh
Name:	glutathione peroxidase 1; targeted mutation 1, Ye-Shih Ho
MGI ID:	MGI:2158814
Synonyms:	Gpx1-, GpX-1 KO, GPX1 KO, GSHPx-1-deficient
Gene:	Gpx1  Location: Chr9:108216279-108217541 bp, + strand  Genetic Position: Chr9, 59.24 cM, cytoband F1
Alliance:	Gpx1tm1Ysh page

Germline Transmission:	Earliest citation of germline transmission: J:41169
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a neomycin resistance cassette disrupted exon 2 of the gene. Northern blots of total RNA isolated from brain, heart, kidney, liver, and lung of homozygous mutant mice showed no detectable transcript of the targeted gene when probed with an a gene-specific cDNA probe. (J:41169)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Gpx1tm1Ysh

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gpx1 Mutation:	21 strains or lines available

Original:	J:41169 Ho YS, et al., Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem. 1997 Jun 27;272(26):16644-51
All:	83 reference(s)