About   Help   FAQ
Sema3atm1.1Tyag
Targeted Allele Detail
Summary
Symbol: Sema3atm1.1Tyag
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; targeted mutation 1.1, Takeshi Yagi
MGI ID: MGI:2158944
Synonyms: Sema3a-, semaphorin III/D null
Gene: Sema3a  Location: Chr5:13175381-13652533 bp, + strand  Genetic Position: Chr5, 4.31 cM
Alliance: Sema3atm1.1Tyag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43443
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: This allele was generated from Sema3atm1Tyag by transient cre expression in TT-2 cells. Recombination produced three alleles, Sema3atm1.1Tyag, Sema3atm1.2Tyag and Sema3atm1.3Tyag. Sema3tm1.1Tyag has had the first exon, including the initiation codon, deleted. (J:43443)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 62 assay results
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sema3a Mutation:  48 strains or lines available
Notes
Homozygous embryos are largely viable after birth but at 4 weeks after birth are about half the body weight of wild-type and have abnormalities in peripheral nerve projection.
References
Original:  J:43443 Taniguchi M, et al., Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 1997 Sep;19(3):519-30
All:  46 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory