Oprm1<tm1Kff> Targeted Allele Detail MGI Mouse (MGI:2159000)

Oprm1^tm1Kff
Targeted Allele Detail

Summary

Symbol:	Oprm1^tm1Kff
Name:	opioid receptor, mu 1; targeted mutation 1, Brigitte L Kieffer
MGI ID:	MGI:2159000
Synonyms:	MOR-
Gene:	Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
Alliance:	Oprm1^tm1Kff page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:36241
Parent Cell Line:	P1 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin selection cassette was inserted into exon 2. Binding assays on brain of homozygous animals confirmed that no functional protein was made from this allele. (J:36241)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:	54 strains or lines available

References

Original:	J:36241 Matthes HW, et al., Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene [see comments]. Nature. 1996 Oct 31;383(6603):819-23
All:	82 reference(s)

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