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Mbtm1Jsc
Targeted Allele Detail
Summary
Symbol: Mbtm1Jsc
Name: myoglobin; targeted mutation 1, Jurgen Schrader
MGI ID: MGI:2159004
Synonyms: myo -
Gene: Mb  Location: Chr15:76899687-76934868 bp, - strand  Genetic Position: Chr15, 36.36 cM
Alliance: Mbtm1Jsc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57481
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2. Northern blot analysis on RNA derived from heart of homozygous mice demonstrated that no detectable transcript is produced from this allele. No encoded protein was present in cardiac protein extracts derived from homozygous mice. (J:57481)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mb Mutation:  20 strains or lines available
References
Original:  J:57481 Godecke A, et al., Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10495-500
All:  14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory