Nr0b1<tm1.1Lja> Targeted Allele Detail MGI Mouse (MGI:2159321)

Nr0b1^tm1.1Lja
Targeted Allele Detail

Summary

Symbol:	Nr0b1^tm1.1Lja
Name:	nuclear receptor subfamily 0, group B, member 1; targeted mutation 1.1, J Larry Jameson
MGI ID:	MGI:2159321
Synonyms:	Ahch^delta2, Dax1-, Dax1KO
Gene:	Nr0b1 Location: ChrX:85235381-85239553 bp, + strand Genetic Position: ChrX, 39.67 cM
Alliance:	Nr0b1^tm1.1Lja page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:51292
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: This allele is a derivative of Nr0b1^tm1Lja in which Cre-mediated recombination in vivo under control of a CMV promoter excised exon 2 in the germline. RT-PCR analyses of pituitary, adrenal glands, and gonads did not detect full length transcript in either homozygous female mice or hemizygous male mice. (J:51292)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Nr0b1 Mutation:	9 strains or lines available

References

Original:	J:51292 Yu RN, et al., Role of Ahch in gonadal development and gametogenesis [see comments]. Nat Genet. 1998 Dec;20(4):353-7
All:	19 reference(s)

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