Gpc3<tm1Fil> Targeted Allele Detail MGI Mouse (MGI:2159356)

Gpc3^tm1Fil
Targeted Allele Detail

Summary

Symbol:	Gpc3^tm1Fil
Name:	glypican 3; targeted mutation 1, Jorge Filmus
MGI ID:	MGI:2159356
Synonyms:	Gpc3 -
Gene:	Gpc3 Location: ChrX:51361303-51702827 bp, - strand Genetic Position: ChrX, 28.74 cM, cytoband A3.3
Alliance:	Gpc3^tm1Fil page

Some Gpc3^tm1Fil/Y embryos exhibit mandibular hypoplasia

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:73877
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin selection cassette replaced a genomic fragment containing part of the promoter and exon 1. Northern blot analysis on RNA derived from E18.5 embryos confirmed that no detectable transcript was produced from this allele. (J:73877)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gpc3 Mutation:	18 strains or lines available

References

Original:	J:73877 Cano-Gauci DF, et al., Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol. 1999 Jul 12;146(1):255-64
All:	7 reference(s)

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