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Casp8tm1Yuan
Targeted Allele Detail
Summary
Symbol: Casp8tm1Yuan
Name: caspase 8; targeted mutation 1, Junying Yuan
MGI ID: MGI:2159369
Synonyms: C8-
Gene: Casp8  Location: Chr1:58834553-58886663 bp, + strand  Genetic Position: Chr1, 29.19 cM, cytoband B
Alliance: Casp8tm1Yuan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49459
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A loxP-flanked neomycin resistance cassette replaced a genomic fragment containing exons 1 and 2, which encode two N-terminal binding motifs. (J:49459)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp8 Mutation:  45 strains or lines available
References
Original:  J:49459 Varfolomeev EE, et al., Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 1998 Aug;9(2):267-76
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory