Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Itgb3tm1Hyn Name: integrin beta 3; targeted mutation 1, Richard Hynes MGI ID: MGI:2175913 Synonyms: beta3-, Beta3, beta3 KO Gene: Itgb3  Location: Chr11:104498826-104561302 bp, + strand  Genetic Position: Chr11, 67.84 cM Alliance: Itgb3tm1Hyn page

Survival of Itgb3tm1Hyn/Itgb3tm1Hyn mice is compromised due to placental defects and hemorrhage Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:52262
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced 1.4 kb of sequence including exons I and II. FACS, immunoprecipitation, and immunofluorescence analyses did not detect protein expression in platelets and MEFs from homozygous mutant animals. (J:52262)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

14 anatomical structure(s)

List all tumor models in MMHCdb carrying Itgb3tm1Hyn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Itgb3 Mutation:	45 strains or lines available

Original:	J:52262 Hodivala-Dilke KM, et al., Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest. 1999 Jan;103(2):229-38
All:	133 reference(s)