Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(Syn1-cre)671Jxm
Name:	transgene insertion 671, Jamey Marth
MGI ID:	MGI:2176055
Synonyms:	cresyn1, Syn-cre, Syn-Cretg, SynI-Cre
Transgene:	Tg(Syn1-cre)671Jxm  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance:	Tg(Syn1-cre)671Jxm page

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Recombinase) Mutations:    Duplication, Insertion   Tg(Syn1-cre)671Jxm expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Syn1 (24949) Syn1  (MGI:98460)   Mutation details: This transgene expresses Cre recombinase under the control of a rat synapsin I promoter. Cre recombinase activity is detected in neuronal cells, including brain, spinal cord and DRGs, as early as E12.5, as well as in neurons in adult. Line 671 contains 10 copies of the transgene inserted into chromosome 6 over 1 Mb from the nearest gene (chr6:10,423,318; NCBI37/mm9) with a duplication of unknown size at the insertion site. (J:68558)

Activity:	Tissue activity of this recombinase allele
Driver:	Syn1 (rat) Summary of all recombinase alleles driven by Syn1. Comparative matrix view of recombinase activities Alliance rat Syn1 gene page
User Notes:	Additional information submitted by the research community Additional information submitted by the research community It was reported by Rempe et al., 2006 (PMID 16419044) that transgene expression in male mice results in germline recombination in progeny.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

9 assay results 2 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Syn1-cre)671Jxm

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
All:	223 reference(s)