Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Nf1tm1Par
Name:	neurofibromin 1; targeted mutation 1, Luis F Parada
MGI ID:	MGI:2176057
Synonyms:	Nf1flox, Nf1flox
Gene:	Nf1  Location: Chr11:79230519-79472438 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Alliance:	Nf1tm1Par page

Germline Transmission:	Earliest citation of germline transmission: J:68558
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP-neomycin selection cassette was inserted into intron 30 and a single loxP site was inserted into intron 32. (J:68558)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	31 anatomical structure(s)

List all tumor models in MMHCdb carrying Nf1tm1Par

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:	161 strains or lines available

Original:	J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
All:	189 reference(s)