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Cyp26b1 Gene Detail
Summary
  • Symbol
    Cyp26b1
  • Name
    cytochrome P450, family 26, subfamily b, polypeptide 1
  • Synonyms
    CP26, P450RAI-2, retinoic acid B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176159
    NCBI Gene: 232174
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:84548396-84570890 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 36.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176159
 protein coding gene Chr6:84548396-84570890 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030945
 protein coding gene Chr6:85681366-85697980 (-)
A/J MGP_AJ_G0030914
 protein coding gene Chr6:82394863-82411466 (-)
AKR/J MGP_AKRJ_G0030842
 protein coding gene Chr6:84792845-84806652 (-)
BALB/cJ MGP_BALBcJ_G0030924
 protein coding gene Chr6:82420630-82437263 (-)
C3H/HeJ MGP_C3HHeJ_G0030786
 protein coding gene Chr6:99629792-99646422 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031384
 protein coding gene Chr6:88028639-88042415 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028570
 protein coding gene Chr6:80740737-80763265 (-)
CAST/EiJ MGP_CASTEiJ_G0030033
 protein coding gene Chr6:84817991-84831897 (-)
CBA/J MGP_CBAJ_G0030611
 protein coding gene Chr6:91505505-91522177 (-)
DBA/2J MGP_DBA2J_G0030764
 protein coding gene Chr6:81702705-81719307 (-)
FVB/NJ MGP_FVBNJ_G0030717
 protein coding gene Chr6:80913721-80937938 (-)
LP/J MGP_LPJ_G0030843
 protein coding gene Chr6:85674759-85688578 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030753
 protein coding gene Chr6:95725276-95741898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031408
 protein coding gene Chr6:84609115-84625731 (-)
PWK/PhJ MGP_PWKPhJ_G0029748
 protein coding gene Chr6:80635931-80658838 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029576
 protein coding gene Chr6:83469606-83483562 (-)
WSB/EiJ MGP_WSBEiJ_G0030114
 protein coding gene Chr6:85050389-85067008 (-)



Homology
more
  • Human Ortholog
    CYP26B1, cytochrome P450 family 26 subfamily B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP26B1, cytochrome P450 family 26 subfamily B member 1
  • Synonyms
    CYP26A2, P450RAI-2, P450RAI2, RHFCA
  • Links
    NCBI Gene ID: 56603
    neXtProt AC: NX_Q9NR63
    UniProt: Q9NR63

  • Chr Location
    2p13.2; chr2:72129238-72147862 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 6 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    4 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice typically show disrupted limb morphogenesis and proximal-distal patterning. Mutant mice are born but die immediately after birth exhibiting respiratory distress. Homozygotes for a null allele show abnormally enlarged aortic valves and ventricular septal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1315
  • Tissues
    368
  • cDNA Data
    35
  • Literature Summary
    114
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232174 NCBI Gene Model | MGI Sequence Detail 22495 C57BL/6J ±  kb
    transcript NM_175475 RefSeq | MGI Sequence Detail 4751 C57BL/6  
    polypeptide Q811W2 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 36
      Primer pair 15
      Other 11

      Microarray probesets 1
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 114
      Gene Ontology 14
      Phenotypes 44
    • Earliest
      J:71426 MacLean G, et al., Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev. 2001 Sep;107(1-2):195-201
    • Latest
      J:350460 Soussi G, et al., TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory