Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(MMTV-cre)1Mam
Name:	transgene insertion 1, Lothar Hennighausen
MGI ID:	MGI:2176165
Synonyms:	A1 line, A-line, CreA, MMTV-Cre, MMTV-CreA, MMTV Cre line A, MMTV-CrelineA
Transgene:	Tg(MMTV-cre)1Mam  Location: unknown
Alliance:	Tg(MMTV-cre)1Mam page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(MMTV-cre)1Mam expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note virus MMTV   Mutation details: This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, the salivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. (J:67925, J:74366)

Activity:	Tissue activity of this recombinase allele
Driver:	MMTV (virus) Summary of all recombinase alleles driven by MMTV.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

104036 assay results 6 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(MMTV-cre)1Mam

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:67925 Wagner KU, et al., Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 1997 Nov 1;25(21):4323-30
All:	92 reference(s)