Smo<tm2Amc> Targeted Allele Detail MGI Mouse (MGI:2176256)

Smo^tm2Amc
Targeted Allele Detail

Summary

Symbol:	Smo^tm2Amc
Name:	smoothened, frizzled class receptor; targeted mutation 2, Andrew P McMahon
MGI ID:	MGI:2176256
Synonyms:	Smo^c, Smo^f, Smo^fl, Smo^flox
Gene:	Smo Location: Chr6:29735502-29761364 bp, + strand Genetic Position: Chr6, 12.36 cM, cytoband A3.3
Alliance:	Smo^tm2Amc page

Intestinal mesenchymal proliferation and expansion are affected in Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:73071
Parent Cell Line:	AV3 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change, Reporter)
Mutation:		Insertion
		Mutation details: Two loxP sites and an frt-flanked neomycin resistance cassette were inserted flanking ~400 bp of the first coding exon 1 from 44 bp upstream through 358 bp downstream of the translation initiation codon. A tau-LacZ gene was also inserted 3' to the neomycin resistance gene. (J:73071)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	356 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	65 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smo^tm2Amc

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Smo Mutation:	39 strains or lines available

References

Original:	J:73071 Long F, et al., Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development. 2001 Dec;128(24):5099-108
All:	205 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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