Mpotm1Mae
Targeted Allele Detail
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| Symbol: |
Mpotm1Mae |
| Name: |
myeloperoxidase; targeted mutation 1, Nobuyo Maeda |
| MGI ID: |
MGI:2176344 |
| Synonyms: |
Mpo- |
| Gene: |
Mpo Location: Chr11:87684610-87695238 bp, + strand Genetic Position: Chr11, 52.22 cM, cytoband C
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| Alliance: |
Mpotm1Mae page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:53993
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| Parent Cell Line: |
BK4 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 6 and 7. Northern blot analysis on bone marrow RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Furthermore, neutrophils and monocytes of homozygous mutant mice were shown to completely lack enzyme activity.
(J:53993)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:53993 Aratani Y, et al., Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun. 1999 Apr;67(4):1828-36 |
| All: |
21 reference(s) |
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Analysis Tools
