Affected Systems |
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adipose tissue
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√
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decreased subcutaneous adipose tissue amount
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√
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cardiovascular system
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√
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abnormal heart development
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√
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cellular
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√
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polyploidy
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√
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abnormal cell death
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√
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decreased cell proliferation
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√
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digestive/alimentary system
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√
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abnormal intestine morphology
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√
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intestinal hypoperistalsis
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√
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embryo
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√
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abnormal gastrulation
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√
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failure of initiation of embryo turning
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√
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abnormal rostral-caudal axis patterning
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√
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caudal body truncation
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√
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embryonic growth arrest
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√
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embryonic growth retardation
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√
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abnormal axial mesoderm morphology
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√
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abnormal neural tube morphology
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√
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abnormal embryonic neuroepithelium morphology
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√
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open neural tube
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√
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kinked neural tube
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√
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abnormal notochord morphology
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√
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incomplete somite formation
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√
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abnormal allantois morphology
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√
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abnormal visceral yolk sac morphology
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√
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abnormal vitelline vascular remodeling
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√
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growth/size/body
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√
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√
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embryonic growth retardation
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√
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cachexia
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√
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postnatal growth retardation
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√
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integument
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√
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decreased subcutaneous adipose tissue amount
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√
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abnormal hair growth
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√
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waved hair
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√
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abnormal hair follicle morphology
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√
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abnormal hair follicle development
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√
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abnormal hair follicle orientation
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√
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decreased hair follicle number
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√
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epidermal atrophy
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√
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thin epidermis
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√
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dry skin
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√
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flaky skin
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√
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abnormal skin condition
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√
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thin skin
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√
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mortality/aging
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√
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√
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postnatal lethality, incomplete penetrance
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√
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embryonic lethality during organogenesis, complete penetrance
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√
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muscle
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√
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intestinal hypoperistalsis
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√
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abnormal muscle morphology
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√
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nervous system
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√
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abnormal neural tube morphology
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√
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abnormal embryonic neuroepithelium morphology
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√
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open neural tube
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√
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kinked neural tube
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√
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respiratory system
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√
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abnormal lung development
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√
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atelectasis
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√
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thick pulmonary interalveolar septum
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√
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abnormal breathing pattern
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√
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vision/eye
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√
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eyelids open at birth
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√
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