Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Nes-cre)1Atp
Name:	transgene insertion 1, Andreas Trumpp
MGI ID:	MGI:2176835
Synonyms:	Nes-Cre1, Nestincre, Nestin-Cre, Tg(Nes-cre)1Mrt
Transgene:	Tg(Nes-cre)1Atp  Location: unknown
Alliance:	Tg(Nes-cre)1Atp page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Nes-cre)1Atp expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Nes (25491) Nes  (MGI:101784)   Mutation details: The 5' region of the rat nestin gene was placed upstream of an NLS-Cre-pA and the rat nestin intron 2. This line carried a single or low copy transgene. The absence of transcript expression was confirmed by RT-PCR on endoneurial extracts. This promoter is active by E9 in the CNS progenitor cells. Transgene is paternally imprinted, thus brain-specific recombination is only 30% when allele is maternally inherited, compared to ~95% with paternal transmission (J:75417, J:121563). (J:58999, J:111945)

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

131 assay results 1 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Nes-cre)1Atp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:58999 Trumpp A, et al., Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 1;13(23):3136-48
All:	81 reference(s)