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Tlr7 Gene Detail
Summary
  • Symbol
    Tlr7
  • Name
    toll-like receptor 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176882
    NCBI Gene: 170743
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:166087925-166113554 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 78.31 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    584 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176882
 protein coding gene ChrX:166086376-166113570 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036271
 protein coding gene ChrX:165479182-165506400 (-)
A/J MGP_AJ_G0036240
 protein coding gene ChrX:164614447-164639968 (-)
AKR/J MGP_AKRJ_G0036170
 protein coding gene ChrX:169895909-169921443 (-)
BALB/cJ MGP_BALBcJ_G0036235
 protein coding gene ChrX:162566747-162592346 (-)
C3H/HeJ MGP_C3HHeJ_G0035942
 protein coding gene ChrX:165783551-165809443 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036758
 protein coding gene ChrX:170275876-170303028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033578
 protein coding gene ChrX:155417353-155442112 (-)
CAST/EiJ MGP_CASTEiJ_G0035229
 protein coding gene ChrX:144660950-144687256 (-)
CBA/J MGP_CBAJ_G0035916
 protein coding gene ChrX:175239566-175266634 (-)
DBA/2J MGP_DBA2J_G0036082
 protein coding gene ChrX:163422122-163447814 (-)
FVB/NJ MGP_FVBNJ_G0036014
 protein coding gene ChrX:162560779-162586306 (-)
LP/J MGP_LPJ_G0036167
 protein coding gene ChrX:166541554-166567146 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036046
 protein coding gene ChrX:183925689-183952576 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036797
 protein coding gene ChrX:164926187-164952745 (-)
PWK/PhJ MGP_PWKPhJ_G0034928
 protein coding gene ChrX:141385053-141411354 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034747
 protein coding gene ChrX:145192887-145217739 (-)
WSB/EiJ MGP_WSBEiJ_G0035365
 protein coding gene ChrX:162772178-162799917 (-)



Homology
more
  • Human Ortholog
    TLR7, toll like receptor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR7, toll like receptor 7
  • Synonyms
    IMD74, SLEB17, TLR7-like
  • Links
    NCBI Gene ID: 51284
    neXtProt AC: NX_Q9NYK1
    UniProt: Q9NYK1

  • Chr Location
    Xp22.2; chrX:12867072-12890361 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tlr7 mouse models; 2 with human TLR7 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 8 alleles in 10 genetic backgrounds
    40 phenotypes from multigenic genotypes
    336 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The innate immune response to viral infection is affected in homozygous null mice. Mice homozygous or hemizygous for a point mutation produce little or no tumor necrosis factor (TNF) alpha in response to stimulation by a single stranded RNA analog.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    42
  • cDNA Data
    11
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044583 Ensembl Gene Model | MGI Sequence Detail 25630 C57BL/6J ±  kb
    transcript ENSMUST00000112164 Ensembl | MGI Sequence Detail 3468 Not Applicable  
    polypeptide ENSMUSP00000107789 Ensembl | MGI Sequence Detail 1050 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000001158 Toll-like receptor 7
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR041283 Leucine-rich repeat unit
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    • GlyGen
      P58681 12 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 496
      Developmental Gene Expression 10
      Diseases 3
      Gene Ontology 18
      Phenotypes 336
    • Earliest
      J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
    • Latest
      J:354283 Wang C, et al., Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production. Commun Biol. 2024 Sep 17;7(1):1162
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory