Brca2<tm1Brd> Targeted Allele Detail MGI Mouse (MGI:2177233)

Brca2^tm1Brd
Targeted Allele Detail

Summary

Symbol:	Brca2^tm1Brd
Name:	breast cancer 2, early onset; targeted mutation 1, Allan Bradley
MGI ID:	MGI:2177233
Synonyms:	Brca2^Brdm1, Brca2^KO, Brca2^tmBrd1
Gene:	Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
Alliance:	Brca2^tm1Brd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39764
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-hprt minigene cassette replaced 2.8 kb of coding sequences corresponding to amino acids 626-1437 of the encoded protein. (J:39764)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm1Brd

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Brca2 Mutation:	132 strains or lines available

References

Original:	J:39764 Sharan SK, et al., Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature. 1997 Apr 24;386(6627):804-10
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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