Brca2<tm1Brd> Targeted Allele Detail MGI Mouse (MGI:2177233)

Brca2^tm1Brd
Targeted Allele Detail

Summary

Symbol:	Brca2^tm1Brd
Name:	breast cancer 2, early onset; targeted mutation 1, Allan Bradley
MGI ID:	MGI:2177233
Synonyms:	Brca2^Brdm1, Brca2^KO, Brca2^tmBrd1
Gene:	Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
Alliance:	Brca2^tm1Brd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39764
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-hprt minigene cassette replaced 2.8 kb of coding sequences corresponding to amino acids 626-1437 of the encoded protein. (J:39764)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1	ht2	ht3		ht4
show or hide all annotated terms Sex:
behavior/neurological			N
behavior/neurological phenotype			N
embryo	√		√	√
embryo phenotype			N	N
abnormal developmental patterning	√
decreased embryo size			√	√
abnormal embryonic tissue morphology	√
abnormal extraembryonic tissue morphology	√
endocrine/exocrine glands			√
abnormal branching of the mammary ductal tree			√
decreased mammary duct terminal end bud number			√
growth/size/body			√	√
growth/size/body region phenotype			N	N
decreased embryo size			√	√
decreased birth body size			√	√
decreased birth weight			√	√
decreased body size			√	√
decreased body weight			√	√
homeostasis/metabolism			√	√
increased mortality induced by ionizing radiation			√	√
integument			√
abnormal branching of the mammary ductal tree			√
decreased mammary duct terminal end bud number			√
mortality/aging	√		√	√
increased mortality induced by ionizing radiation			√	√
premature death			√	√
prenatal lethality, complete penetrance	√
prenatal lethality, incomplete penetrance			√	√
neoplasm			N	N
neoplasm			N	N
reproductive system			N	N	N
reproductive system phenotype			N	N	N
normal phenotype		√
no abnormal phenotype detected		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm1Brd

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Brca2 Mutation:	133 strains or lines available

References

Original:	J:39764 Sharan SK, et al., Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature. 1997 Apr 24;386(6627):804-10
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24