Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Tg(KRT14-cre)8Brn Name: transgene insertion 8, Anton Berns MGI ID: MGI:2177243 Synonyms: K14cre, K14-Cre, Tg(K14-Cre)8Brn, Tg(KRT14-cre)1Brn Transgene: Tg(KRT14-cre)8Brn  Location: unknown   Alliance: Tg(KRT14-cre)8Brn page

Histological and Immunochemical examinaton of skin and teeth of Apctm2Rak/Apctm2Rak Tg(KRT14-cre)8Brn/0 mice at P12 Show the 10 phenotype image(s) involving this allele.

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(KRT14-cre)8Brn expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human KRT14 (3861) Krt14  (MGI:96688)   Mutation details: This transgene expresses Cre recombinase under the control of a human keratin 14 promoter. This promoter is active in skin, salivary gland and mammary gland epithelium. Mammary gland epithelium recombination efficiency was estimated at a weak 5-30%. (J:73028)

Activity:	Tissue activity of this recombinase allele
Driver:	KRT14 (human) Summary of all recombinase alleles driven by KRT14. Comparative matrix view of recombinase activities Alliance human KRT14 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(KRT14-cre)8Brn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available

Original:	J:73028 Jonkers J, et al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001 Dec;29(4):418-25
All:	127 reference(s)