Gata1<tm2Sho> Targeted Allele Detail MGI Mouse (MGI:2177586)

Gata1^tm2Sho
Targeted Allele Detail

Summary

Symbol:	Gata1^tm2Sho
Name:	GATA binding protein 1; targeted mutation 2, Stuart Orkin
MGI ID:	MGI:2177586
Synonyms:	GATA-1^low, neo deltaHS, neodeltaHS
Gene:	Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
Alliance:	Gata1^tm2Sho page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:41605
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP-flanked neomycin selection cassette replaced the "IT" and DNAseI hypersensitive region of the promoter. RT-PCR experiments demonstrated that this mutation resulted in the loss of expression in megakaryocytes and fetal liver but not in erythroid cells. (J:41605)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gata1 Mutation:	45 strains or lines available

References

Original:	J:41605 Shivdasani RA, et al., A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 1;16(13):3965-73
All:	21 reference(s)

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