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Gata1tm2.1Sho
Targeted Allele Detail
Summary
Symbol: Gata1tm2.1Sho
Name: GATA binding protein 1; targeted mutation 2.1, Stuart Orkin
MGI ID: MGI:2177587
Synonyms: deltaneo deltaHS, deltaneodeltaHS, Gata1deltaneodeltaHS, GATA-1 knock-down
Gene: Gata1  Location: ChrX:7825504-7842844 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Alliance: Gata1tm2.1Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41605
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: This allele is similar to Gata1tm2Sho but the loxP flanked neomycin selection cassette was deleted in ES cells by transient Cre expression prior to the production of chimeric mice. RT-PCR shows that expression is reduced in megakaryocytes. (J:41605)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:  45 strains or lines available
References
Original:  J:41605 Shivdasani RA, et al., A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 1;16(13):3965-73
All:  19 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory