Htt<tm2Szi> Targeted Allele Detail MGI Mouse (MGI:2177755)

Htt^tm2Szi
Targeted Allele Detail

Summary

Symbol:	Htt^tm2Szi
Name:	huntingtin; targeted mutation 2, Scott Zeitlin
MGI ID:	MGI:2177755
Synonyms:	Hdh^flox
Gene:	Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
Alliance:	Htt^tm2Szi page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:65520
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A neomycin selection cassette followed by a loxP site was inserted 5' to exon 1 and a single loxP site was inserted 3' to exon 1. (J:65520)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Htt Mutation:	178 strains or lines available

References

Original:	J:65520 Dragatsis I, et al., Inactivation of hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet. 2000 Nov;26(3):300-6
All:	18 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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