Il11ra1tm1Gos
Targeted Allele Detail
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| Symbol: |
Il11ra1tm1Gos |
| Name: |
interleukin 11 receptor subunit alpha 1; targeted mutation 1, Achim Gossler |
| MGI ID: |
MGI:2177774 |
| Synonyms: |
Il11ra1TgH(PGKneo)7Gos, IL-11RalphaTgH(PGK-neo) |
| Gene: |
Il11ra1 Location: Chr4:41760443-41769473 bp, + strand Genetic Position: Chr4, 21.94 cM
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| Alliance: |
Il11ra1tm1Gos page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:48920
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| Parent Cell Line: |
D3 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A targeting event resulted in the insertion of a neomycin resistance gene into intron 8, followed by a truncated, promoterless Il11ra1 gene lacking exons 2-13. Northern blot experiments on RNA derived from kidney of homozygous mice demonstrated that an aberrant transcript was produced from this allele. It was a size consistent with the splicing around the neo cassette to produce a transcript that contains exon 1-8 fused to exons 2-13. Western blot analysis on kidney extracts confirmed that an aberrantly sized protein was expressed from this allele, although at lower levels than Il11ra1tm2Gos.
(J:48920)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Il11ra1 Mutation: |
37 strains or lines available
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| Original: |
J:48920 Bilinski P, et al., Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Genes Dev. 1998 Jul 15;12(14):2234-43 |
| All: |
2 reference(s) |
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Analysis Tools
