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Wnt2tm1Bjw
Targeted Allele Detail
Summary
Symbol: Wnt2tm1Bjw
Name: wingless-type MMTV integration site family, member 2; targeted mutation 1, Brandon J Wainwright
MGI ID: MGI:2177935
Gene: Wnt2  Location: Chr6:17988939-18030584 bp, - strand  Genetic Position: Chr6, 8.08 cM, cytoband A2-A3.1
Alliance: Wnt2tm1Bjw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36835
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A neomycin resistance cassette was inserted into exon 3. RT-PCR analysis in RNA derived from lung and heart demonstrated that aberrant trancripts were made from this allele, but none are expected to encode a functional protein. (J:36835)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt2 Mutation:  26 strains or lines available
References
Original:  J:36835 Monkley SJ, et al., Targeted disruption of the Wnt2 gene results in placentation defects. Development. 1996 Nov;122(11):3343-53
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory