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Hiratm1Pjs
Targeted Allele Detail
Summary
Symbol: Hiratm1Pjs
Name: histone cell cycle regulator; targeted mutation 1, Peter J Scambler
MGI ID: MGI:2178130
Synonyms: Hiraneo
Gene: Hira  Location: Chr16:18695787-18789059 bp, + strand  Genetic Position: Chr16, 11.69 cM, cytoband A-B1
Alliance: Hiratm1Pjs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75491
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: All of the coding sequence of exon 8 after amino acid position 183 was replaced with a neo/leu2 cassette. RT-PCR and western blotting experiments demonstrated an absence of encoded transcripts and protein, respectively. (J:75491)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hira Mutation:  74 strains or lines available
References
Original:  J:75491 Roberts C, et al., Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory