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Foxa3tm1Khk
Targeted Allele Detail
Summary
Symbol: Foxa3tm1Khk
Name: forkhead box A3; targeted mutation 1, Klaus H Kaestner
MGI ID: MGI:2178218
Synonyms: Hnf3g-
Gene: Foxa3  Location: Chr7:18747209-18757463 bp, - strand  Genetic Position: Chr7, 9.46 cM
Alliance: Foxa3tm1Khk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17631
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A cassette containing lacZ and neo was replaced most of the coding region and 5.5 kb of 3' flanking sequence. While expression of lacZ was observed in nasal and colonic epithelia, it was unobserved in the liver, pancreas, stomach, and small intestines. This lack of expression was attributed to the deletion of cis regulatory elements located in the 3' flanking region of the endogenous gene. (J:17631, J:48310)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxa3 Mutation:  19 strains or lines available
References
Original:  J:17631 Kaestner KH, et al., The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics. 1994 Apr;20(3):377-85
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory