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Myctm2Fwa
Targeted Allele Detail
Summary
Symbol: Myctm2Fwa
Name: myelocytomatosis oncogene; targeted mutation 2, Frederick W Alt
MGI ID: MGI:2178233
Synonyms: c-mycfl, MYCfl, Mycflox, Myclox
Gene: Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance: Myctm2Fwa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67222
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A single loxP site was inserted into intron 1 and a loxP-flanked neomycin selection cassette was inserted 3' to exon 3. The neomycin cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. (J:67222)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 103 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 2 lines available
Carrying any Myc Mutation:  43 strains or lines available
References
Original:  J:67222 de Alboran IM, et al., Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001 Jan;14(1):45-55
All:  128 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory