Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: EgfrWa5 Name: epidermal growth factor receptor; waved 5 MGI ID: MGI:2178387 Synonyms: Gena239, GENA 239 Gene: Egfr  Location: Chr11:16702203-16868158 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4 Alliance: EgfrWa5 page

Phenotypes of Egfrwa2/EgfrWa5 and Tgfatm1Unc/Tgfatm1Unc EgfrWa5/+ mice Show the 2 phenotype image(s) involving this allele.

Strain of Origin:	BALB/cAnN
Project Collection:	Harwell ENU Mutagenesis

Allele Type:    Chemically induced (ENU) (Not Applicable) Mutation:    Single point mutation   Mutation details: Originally named Waved 5, this phenotypic mutant was deemed allelic to Egfr when it failed to complement Egfrtm1Mag. The entire coding region of Egfr was subsequently sequenced. A single point mutation was found causing a GAT to GGT missense mutation in exon 21. This results in an aspartic acid to glycine change at amino acid residue 833 altering a DFG motif critical to the tyrosine kinase function of this gene. (J:75964, J:92308) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

List all tumor models in MMHCdb carrying EgfrWa5

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:	87 strains or lines available

Original:	J:75964 Thaung C, et al., Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet. 2002 Apr 1;11(7):755-67
All:	24 reference(s)