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Drd4tm1Dkg
Targeted Allele Detail
Summary
Symbol: Drd4tm1Dkg
Name: dopamine receptor D4; targeted mutation 1, David K Grandy
MGI ID: MGI:2178631
Synonyms: D4-, D4KO, D4R -, Drd4-
Gene: Drd4  Location: Chr7:140871931-140874868 bp, + strand  Genetic Position: Chr7, 86.6 cM
Alliance: Drd4tm1Dkg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43061
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced exon 2. RT-PCR analysis demonstrated that a mutated transcript was produced from this allele that spliced exon 1 to exon 3. This mutation causes a shift in the reading frame that is predicted to result in the production of a truncated protein. (J:43061)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd4 Mutation:  33 strains or lines available
References
Original:  J:43061 Rubinstein M, et al., Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell. 1997 Sep 19;90(6):991-1001
All:  39 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory