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Tlr2tm1Aki
Targeted Allele Detail
Summary
Symbol: Tlr2tm1Aki
Name: toll-like receptor 2; targeted mutation 1, Shizuo Akira
MGI ID: MGI:2178675
Synonyms: Tlr2-, TLR2 KO, TLR2KO
Gene: Tlr2  Location: Chr3:83743579-83749045 bp, - strand  Genetic Position: Chr3, 37.4 cM
Alliance: Tlr2tm1Aki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76115
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neo cassette replaces the part of the exon that encodes the transmembrane and the cytoplasmic domain of this single exon gene. The absence of transcript was confirmed by Northern analysis of peritonel macrophages. (J:76115, J:91950)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Tlr2 Mutation:  60 strains or lines available
References
Original:  J:76115 Takeuchi O, et al., Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999 Oct;11(4):443-51
All:  640 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory