Nfib<tm1Hsch> Targeted Allele Detail MGI Mouse (MGI:2178748)

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Nfib^tm1Hsch
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Nfib^tm1Hsch
Name:	nuclear factor I/B; targeted mutation 1, Heinrich Schrewe
MGI ID:	MGI:2178748
Synonyms:	Nfib^E2-lacZ
Gene:	Nfib Location: Chr4:82208410-82424988 bp, - strand Genetic Position: Chr4, 38.4 cM, cytoband C4-C6
Alliance:	Nfib^tm1Hsch page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:75698
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A lacZ reporter gene was inserted in frame into the DNA binding domain of exon 2. A Nfib-lacZ fusion mRNA is generated containing only the first 11 codons of the Nfib gene. (J:75698)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nfib Mutation:	91 strains or lines available

References

Original:	J:75698 Grunder A, et al., Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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