Casp3<tm1Mak> Targeted Allele Detail MGI Mouse (MGI:2178778)

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Casp3^tm1Mak
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Casp3^tm1Mak
Name:	caspase 3; targeted mutation 1, Tak W Mak
MGI ID:	MGI:2178778
Synonyms:	Casp3^-, CPP32^ex3-
Gene:	Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
Alliance:	Casp3^tm1Mak page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:74972
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment containing exon 3 was replaced with a neomycin selection cassette. Western blot analysis on lysates derived from doubly targeted ES cells confirmed that no detectable protein was produced from this allele. (J:74972)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Casp3 Mutation:	33 strains or lines available

References

Original:	J:74972 Woo M, et al., Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 1998 Mar 15;12(6):806-19
All:	25 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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