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Spo11tm1Mjn
Targeted Allele Detail
Summary
Symbol: Spo11tm1Mjn
Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1, Maria Jasin
MGI ID: MGI:2178805
Synonyms: Spo11-, Spo11tm1Sky, Spotm1M
Gene: Spo11  Location: Chr2:172819493-172835369 bp, + strand  Genetic Position: Chr2, 95.64 cM, cytoband H4
Alliance: Spo11tm1Mjn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65880
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 4-6 of this gene were replaced with a neomycin resistance cassette via homologous recombination thus deleting the putative catalytic tyrosine in exon 5. Northern blot assay failed to detect gene transcripts in testes of homozygous mutant males. (J:65880)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Spo11 Mutation:  21 strains or lines available
References
Original:  J:65880 Baudat F, et al., Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking spo11. Mol Cell. 2000 Nov;6(5):989-98
All:  71 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory