Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Tg(Camk2a-tTA)1Mmay
Name:	transgene insertion 1, Mark Mayford
MGI ID:	MGI:2179066
Synonyms:	CamDAT, CaMKIIalpha-tTA, CaMKII-tTA, CAMK-rTA, line B, pCaMKII-tTA, Tgalpha-CaMkII-tTA, Tg(CaMKIItTA)Mmay
Transgene:	Tg(Camk2a-tTA)1Mmay  Location: Chr12:116064774-116572891 bp  Genetic Position: Chr12, Syntenic
Alliance:	Tg(Camk2a-tTA)1Mmay page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Null/knockout, Transactivator) Mutations:    Insertion, Intergenic deletion, Intragenic deletion   Mutation details: The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. The transgene integrated into chromosome 12 causing a 508.12 Kb deletion and disrupting the following genes: Vipr2, Wdr60, Esyt2, Ncapg2, and Ptprn2. The deletion results in a functional knock-out of Vipr2, Wdr60, Esyt2, and Ncapg2 in homozygous mice. Founder line 1 has a copy number of greater than 20. (J:37107)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 8 strains available      Cell Lines: 0 lines available

Original:	J:37107 Mayford M, et al., Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996 Dec 6;274(5293):1678-83
All:	469 reference(s)