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Rad23btm1Gvh
Targeted Allele Detail
Summary
Symbol: Rad23btm1Gvh
Name: RAD23 homolog B, nucleotide excision repair protein; targeted mutation 1, Gijsbertus T J van der Horst
MGI ID: MGI:2179121
Synonyms: mHR23B-
Gene: Rad23b  Location: Chr4:55350043-55392237 bp, + strand  Genetic Position: Chr4, 29.7 cM, cytoband B3
Alliance: Rad23btm1Gvh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74288
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 3 was replaced with a neomycin cassette via homologous recombination resulting in a frameshift and the deletion of amino acids 148-228. Gene expression could not be detected in Northern and Western blot of mouse embryonic fibroblasts from homozygous mutant E13.5 embyros. (J:74288)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad23b Mutation:  42 strains or lines available
References
Original:  J:74288 Ng JM, et al., Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Mol Cell Biol. 2002 Feb;22(4):1233-45
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory